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4 patients (0.2 cases per 100 patient-years) receiving placebo

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Int Biodeterior Biodegrad 65:733743 Ferraz ERA, Umbuzeiro GAG, Caloto-Oliveira A, Chequer FMD, Zanoni MVB, Dorta DJ, Oliveira DP (2011) Differential toxicity of disperse red 1 and disperse red 13 in the Ames test, HepG2 cytotoxicity assay, and Daphnia acute toxicity test

However, leptin replacement does not completely prevent the neuroendocrine adaptations induced by weight loss 1, 3, 5 , indicating the existence of critical additional, but still unknown, starvation signals